Category Archives: Medieval

Treating the Stone in Sixteenth-Century Wales (According to the Vicar of Gwenddwr)

By Diana Luft

Image of the village of Gwenddwr. Permission granted by the owner of the website Radnorshire Images (John Crellin).
Image of the village of Gwenddwr. Permission granted by the owner of the website Radnorshire Images (John Crellin).

National Library of Wales MS. Peniarth 182 is a miscellany in the hand of Huw Pennant, a poet who lived and worked in Gwynedd and then Carmarthenshire at the turn of the sixteenth century.[1] The manuscript has the look of a personal collection, and it was written over a period of five years, from 1509 until the scribe’s death in 1514. It contains pedigrees, chronicles, religious texts, and texts of a medical nature, including a list of the dangerous days of the year, a short herbal based on Macer Floridus, and two collections of medical recipes. These collections are united by their subject: they all treat the condition tostedd or bladder stone. The first collection has been gleaned from a medieval source; its five recipes can be traced to the four earliest medical manuscripts in Welsh. The second is a mix of recipes that can be traced to fourteenth- and fifteenth-century sources, with the addition of a unique remedy ascribed to an unnamed Vicar of Gwenddwr in Breconshire.

Writing in 1801, Theophilus Jones described the village of Gwenddwr as ‘a vile assortment of huts’, adding that, ‘the best fabric in it is the alehouse’.[2] It may be that the village had fallen on hard times by the nineteenth century, as it seems that its sixteenth-century vicar was recommending a rather complicated, and expensive, course of treatment for bladder stones. Here is the recipe in full:

Rhag y tostedd, medd Bickar Gwenddwr

Kymer ddyrnaid o saets, a’r gymaint arall o’r persli gwraidd ag oll, a’r gymaint arall o’r alisander, a’r gymaint arall o’r ‘selver’ (yr hwn a elwir kynga’r koed), a’r gymaint arall o’r ‘mors off maed lik’ (hynny ydyw, barfav kennin o’r rai ni fflannwyd yn y blaen), a xxxiii o rawn yr eiddaw, a dyrnaid o’r ‘betoni’ (yr rain a elwir kribe sanffred). Golch yn lan hwynt a phwnia mewn mortar kyn vaned a’r grinsaws. Yn ol hyny, bwrw hwynt mewn llestyr glan olchiad, a bwrw arnvn yno dri chwart o hengwrw kadarn, a thri chwart eraill o Rwmnai da. Kymered wraig a dwylaw glan olchiad, a gwasged hwynt hyd pan el ffrwyth y llysiav yn y ddiod. Oddyno kymrud lliain glan a’i hidlo ef yn dda, oddyno bwrw ymaith y soeg, oddyno brew y ddiod hyd pan el chwart o’r chwech chwart dan y brew. Oddyno yskimma ef yn lan, ag oddyno tyn y ddiod oddiar y tan, a bwrw ar y ddiod geinhiagwerth o’r graynys, a dimewerth o’r coleandur,  keinhiagwerth o bowdwr syngir, dimewerth o bowdwr galingall, gwerth tair keinioc o saffrwm, dimewerth o bowdwr licorys. Dod y ddiod ar y tan a gad i verwi ias vechan i gymryd ffrwyth y llysiav. Oddyno tyn i’r llawr, a phan oero ef ddigon, dyro dy ddiod mewn llestyr pridd. Ystopia ef yn dda a lliain glan, a gad yno i sefyll dridiav a theirnos. Yn ol hynny, hidler y ddiod drwy liain glan a rodder i’r glaf y’w yfed yn oer y bore a’r nos, yngwres y gwaed. Arvered o hyn, a iach vydd drwy nerth Duw. Poed gwir Amen

For the stone, says the Vicar of Gwenddwr

Take a handful of sage and the same amount again of parsley, roots and all, and the same amount again of alexanders and the same amount again of ‘cleavers’ (which are called wood burdock), and the same amount again of ‘moss of leek cuttings’ (that is, the beards of leeks which have not been planted before),[1] and thirty-three ivy seeds, and a handful of ‘betony’ (which are called St. Brigid’s combs). Wash them clean and pound them in a mortar as fine as green sauce. After that, put them into a newly-washed vessel and add three quarts of strong old beer, and three more quarts of good Rumney wine. Let a woman with newly-washed hands be brought, and let her press them until the essence of the herbs goes into the liquid. Take a clean linen cloth and strain it well, and throw away the residue, then boil the liquid until one of the six quarts boils away. Skim it clean, remove the liquid from the heat, and add a penny’s-worth of grains of paradise, a halfpenny’s-worth of coriander, a penny’s-worth of ginger powder, a halfpenny’s-worth of galangal powder, three penny’s-worth of saffron, and a halfpenny’s-worth of liquorice powder. Put the liquid on the heat and let it boil for a little while to take the essence of the herbs. Then put it aside, and when it cools enough, put the liquid into an earthenware vessel. Stop it up well with a clean linen cloth and leave it to stand three days and three nights. After that, let the liquid be strained through a clean linen cloth and let it be given to the sick person to drink cold in the morning and at body temperature at night. Let him use this and he will be healed through the strength of God, Amen.

While Pennant’s text is in Welsh, the vicar’s original recipe was likely in English. Most of the ingredients are given in Welsh, but three are in English with Welsh explanations (cleavers, leek grass, and betony). It is not uncommon for Welsh recipes to use English borrowings, especially for foreign or exotic ingredients. The medieval recipe collections contain ingredients such as alym (alum), arment (arnament), atrwm (atrament), brwnston (sulphur), cod (cobbler’s wax), kopros (copperas), and opium. But the English words in this recipe do not refer to foreign or exotic ingredients, rather they indicate the common native herbs. The names of the imported ingredients are borrowings, but they are very old borrowings which have already been incorporated into Welsh. For example, the form coleandur (coriander) appears in Welsh in the earliest herbal glossary, while saffrwm (saffron), licorys (liquorice), and syngir (ginger) are found in the fourteenth-century recipe collections. Thus, while the imported ingredients in this recipe are borrowings, it is the explanations of the common herbs which indicate an English source.

Urine wheel from a fifteenth-century Welsh medical manuscript, NLW 3026 (Mostyn 88), a medical miscellany in the hand of the prolific scribe and poet Gutun Owain. Permission granted by National Library of Wales.
Urine wheel from a fifteenth-century Welsh medical manuscript, NLW 3026 (Mostyn 88), a medical miscellany in the hand of the prolific scribe and poet Gutun Owain. Permission granted by National Library of Wales.

Pennant does not say how he has come by this recipe, whether he has copied it from a book, received it from a friend or neighbour, or perhaps been in correspondence with the vicar himself.  This is the last remedy in this manuscript, all of which treat a common and very painful condition. The collections of remedies in this manuscript, written over a period of years, all treating the same condition, beginning with old remedies taken from manuscripts and ending with what may be the result of correspondence with a contemporary, seems to tell a tale of increasing desperation in the face of an intractable illness. It is impossible to say whether Huw Pennant suffered from bladder stones himself, but the medical texts he chose to include in his collection would seem to suggest that he did. They would also seem to suggest that his interest in these remedies was not academic, but rather practical, that is, that he intended to use them, and may have done so. The cause of Pennant’s death is not recorded. I can only hope that, whatever it was, he received some relief from the ailment that seems to have plagued him for so long.

[1]      This seems to be a reference to the propagation of leeks by removing the seed from the seed head and allowing the head to develop small clones of the parent plant upon it (leek grass), which can then be planted out. I have interpreted mors as representing English ‘moss’, in the sense of a plant resembling moss (OED ‘moss, n.1’ II.4) or perhaps ‘hairiness’ (MED ‘mos’ 1(a)), and maed as representing English ‘math’ that is, a cutting or a mowing, from Anglo-Saxon mæð (OED ‘math, n.1’) and thus mos off maed lik as a cutting of leek, which results in the production of leek grass which is hairy or moss-like in appearance.

[1]      On Huw Pennant see Cartwright, J. 2016. The Middle Welsh Life of St. Ursula and the 11,000 Virgins. In Cartwright, J. ed. The Cult of St. Ursula and the 11,000 Virgins. Cardiff: UWP, pp. 163–86.

[2]      Jones, T. 1809. The History of the County of Brecknock. Vol. 2 of 2. Brecknock: George North, p. 296. You can judge for yourself, from the photograph of the village taken by John Crellin in 2011 for his Radnor Images website (www.radnorimages.co.uk) and used with his kind permission here, whether Jones’s opinion holds true today!

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Diana Luft is a Wellcome Trust Research Fellow at the University of Wales Centre for Advanced Welsh and Celtic Studies. She is currently working on a project called ‘Medieval Welsh Medicine: A new Approach’. The aim of this project is to produce new editions and translations of the Welsh medical texts from the four fourteenth-century manuscripts which represent the first witnesses to such texts in Welsh.

What lies behind the name? Rest-harrow – A medieval herbal enigma

By Theresa Tyers

‘Mystery, magic and medicine: in the beginning they were one and the same’ so begins Howard Haggard’s 1930s book on the rise of scientific medicine.[1] Exploring medieval manuscripts reveals how magical recipes, charms, amulets and ritual healing all formed part of the everyday ‘medicine chest’ of treatments which were intended to deal with a myriad of conditions. Vernacular plant names are fascinating they can be a key to their uses, for example consoude or bonewort, toutsain, (all-heal) or the astringent sanguines. To modern ears the magical sound of: foxgloves, archangel, biting-grass, moonwort or even weasel-tongue can conjure up images in our minds of strange and wondrous plants. Perhaps the most appealing are those rare vernacular names that bring to life the people who may have encountered the plants as they went about their daily life, whether working out in the field ploughing and sowing, or pilgrims travelling long distances by foot along the byways and highways of medieval England and Europe. They would have had ample time to take in their surroundings as the seasons past slowly by and, take note of the notorious twisted rooted wild pink vetch today called ‘rest-harrow’. The ploughman would have easily recognised this troublesome plant and no doubt dreaded its presence. He knew that if he was to clear the land of this tenacious ‘weed’ it would need to be ploughed well and each piece of the noxious root had to be cleared away before the crop could be set.

Common Restharrow (Ononis repens) flower at Stevenston Beach Local Nature Reserve, North Ayrshire, Scotland. Image courtesy of wikicommons.
Common Restharrow (Ononis repens) flower at Stevenston Beach Local Nature Reserve, North Ayrshire, Scotland. Image courtesy of wikicommons.

Sometime ago I also stumbled across ‘rest-harrow’ but this time it was not in a field but in a reference to an intriguing remedy, one which had been added to others in a popular compilation known as the Lettre d’Hippocrate (MS Oxford, Bodley 86).[2] In this post, I’m going to look at three examples of the use of rest-harrow in medieval remedies which were intended to treat diarrhoea. The remedy is, on the whole, the same one that appears elsewhere around this time. However, there are differences between the versions recorded in these three examples and it is these intriguing differences that prompted me to dig a little further!

The late thirteenth-century manuscript MS Cambridge, Trinity College, O.1.20 is one of the earliest vernacular collections of medical texts, written in French, that we have. The remedy that calls for rest-harrow appears to suggest a magical or ritual element to the healing practice. In this rhymed collection of recipes and remedies ‒ the Physique rimee the author claims that he was compiling the knowledge to introduce those who ‘have no Latin (l. 86) to the useful properties of herbs and plants’, the names of which he notes ‘may already be familiar to them’.[3](Hunt, 1989:144). Among the plants he cites is l’arestboef, a name which is echoed today in the French common-name of L’arrêt-boeuf (Ononis arvensis) and in the English ‘rest-harrow’.

Rest-harrow in the field seek it out

It will be pounded and crushed and cooked,

Then tip this [mixture] into a bowl,

Put into [this bowl] the patient’s feet

So long as their feet are kept in there

To move [go forward] they will have no desire.[4]

A ploughman depicted in a manuscript copy of William Langland’s Piers Plowman (Cambridge, Trinity College, R.3.14, fol. 1v), courtesy of the Master and Fellows of Trinity College Cambridge.
A ploughman depicted in a manuscript copy of William Langland’s Piers Plowman (Cambridge, Trinity College, R.3.14, fol. 1v), courtesy of the Master and Fellows of Trinity College Cambridge.

The compiler who made a number of additions to a group of practical remedies for menesiun in Oxford, Bodleian Library, MS Digby 86 also recommended the recipe for its use for diarrhoea but perhaps doubting the rationale behind the author of MS CTC O.1.20’s advice he amends the remedy. His version calls for the patient’s legs and knees to be washed often in the concoction while placed in the bowl and he then places the cause of its efficacy firmly in the hands of God.[5] . There is no mention here of the idea which links the efficacy of the treatment with the time spent soaking the legs in the herbal mixture. The final example of the medieval use of this recipe is also cited in a collection that was copied in 1313, (MS CTC O.5.32, Trinity Practica) and although it shares a number of remedies and recipes in common with MS CTC O.1.20 the author, once again, leaves out the reference to ‘rest-harrow’, its connection with ploughing and its supposed efficacy in the treatment of diarrhoea. In this remedy the reference to oxen is reduced to homely instructions which explains that one simply has to cook ‘rest-harrow’ as one would cook the meat from the same beast.[6]

 The traditional use of rest-harrow for urinary problems and stone is well-documented in Herbals and other recipe and remedy collections. The tenacious growing habit of this plant is also evident in the way in which it appears, once again, in later herbals. In 1640 John Parkinson, accustomed to citing the virtues of rest-harrow for urinary problems, gives a number of remedies for the condition in his monumental work Theatrum Botanicum.[7]

The said quantite of the rootes sliced and put into a stone pot close stopped with the like quantite of wine and so set to boil in a ‘Balneo Marie’ for 24 houres is a daintie a medicine for tender stomacks as any of the daintiest Lady in the Land can desire to take being troubled with any of the aforesaid griefes:.[8]

This remedy, tasting sweetly of liquorice, is a far cry from that of the down to earth compiler of the Physique rimee, who cited its use for diarrhoea, and knew of rest-harrow’s infamous reputation for stopping both the oxen in their tracks and their unfortunate ploughman. Perhaps the answer to the conundrum is that he added his own little twist to the remedy in an attempt to help his students. He made the link of the image of the ploughman behind his plough battling with the ‘rest-harrow’ to provide an aide memoire for his students, who already knew the names of plants, but not their hidden virtues. Subsequent authors, unsure of the empirical authenticity behind its efficacy, quickly dropped this author’s curious explanation so that its use in treating diarrhoea has become an intriguing medieval enigma.

MS Cambridge, Cambridge University Trinity College O.1.20 fol. 7va here. Courtesy of the Master and Fellows of Trinity College Cambridge.
MS Cambridge, Cambridge University Trinity College O.1.20 fol. 7va here. Courtesy of the Master and Fellows of Trinity College Cambridge.

 

 

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Footnote: In preparing this piece for the blog I wanted to make sure that there was no evidence that Ononis arvensis (or its relations) had been traditionally used for treating cases of diarrhoea. Anne Stobart and members of the History of Herbal Medicine group quickly responded to my request for advice on its uses. Dr. Henry Oakeley (Royal College of Physicians) and John Adams (Syon Abbey) also provided me with confirmation of its use which they had gleaned from a wide range of Herbals across historical time periods. Everyone’s input, on the whole, confirmed that this medicinal remedy is not usually cited for diarrhoea and as such it remains a medieval medicinal enigma. My grateful thanks to everyone for their help and advice.

[1] Haggard H. Mystery, Magic, and Medicine. New York: Doubleday, Doran & Company, Inc.; 1933.

[2] Tony Hunt, Popular Medicine in Thirteenth-Century England, D.S. Brewer: 1989, 141.

[3] Hunt, 1989: 144.

[4] L’arestboef ens el chaump querés, Triblé sera, puis le quirés, Puis le versés en une gate, Les piés metes ens au malade. Taunt com les piés la dedens tendra, D’aler avaunt talent n’avra. [4] (Hunt, 1989: 167)          

[5] Et face laver ses genoilz et ses jambs de cel ewe et ceo sovent, si estaunchira od l’aide de Deu

[6]E pernez restbuef e quisez en ewe cum char de buef, destemprez ses pes leinz sic haut cum il purra soufrir, si garra”, Hunt, Anglo-Norman Medicine II, Shorter Treatises, 1997: 273.

[7] For an example of its inclusion in household books see: Elaine Leong, ‘Herbals she peruseth’: reading medicine in early-modern England, Renaissance Studies, 2014

[8] Open access: http://onlinelibrary.wiley.com/doi/10.1111/rest.12079/full DOI: 10.1111/rest.12079

Illustrated Recipes in Crophill’s Cookery

By Sarah Peters Kernan

While I was researching medieval and early modern cookeries for my dissertation, I came across several manuscripts that were notable in one regard or another but they did not make it into my final document. In the hope of inspiring further research, I am focusing on one of these books here. London, British Library, MS Harley 1735 is a fifteenth-century manuscript owned by a rural physician, John Crophill. This manuscript contains a cookery (fols. 16v–28v), remarkable not necessarily for its recipes, but its context and marginalia.

Harley 1735 is one of at least twelve cookeries located in manuscripts owned by medical professionals in fifteenth-century England. I have argued that these cookeries were primarily used as aspirational texts.[1] Professionals could learn about the foods they should aspire to eat as members of a rising social group. While occasional recipes may have been useful in their household kitchens or medical practices, the codicological context of these cookeries suggests that readers used the texts to familiarize themselves with what had been served to their social superiors as a way to fit in and excel in a new social environment. Recipes were a vehicle for shaping a group’s new identity.

The marginalia of Harley 1735 begs for a closer look, as it contains not textual notes, but illustrations. I cannot begin to describe my excitement when I first opened this manuscript! Expecting to see a plain text in black ink with occasional rubrication, I was delighted to see abundant marginal sketches of animals, fruits, nuts, vegetables, and cooking implements. While some other contemporary English and French manuscripts contain a sketch or two of distillation stills or fish (and one instance of a diagram for food preparation), this cookery contains tens of drawings on multiple folios. Furthermore, the sketches align with the recipes. Since all of the drawings are marginal and not integrated into the text, it is safe to assume that they were added after the cookery was copied.

Harley 1735, fol. 18r contains sketches of a dog, swan, rabbits, and grains of wheat. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f018r. (c)British Library Board Harley MS 1735
Harley 1735, fol. 18r contains sketches of a dog, swan, rabbits, and grains of wheat. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f018r. (c)British Library Board Harley MS 1735

While there are marginal sketches in other texts in the same manuscript, it is difficult to say with certainty that Crophill himself added the sketches. None of the images depict cooking actions or processes, but all of the drawings refer to ingredients in the recipes or an implement required to carry out the recipe. There is one exception: a sketch of a dog appears on a leaf with recipes for “Chaudon sauȝ of swannes,” “Amydoun,” and “Conyes in graue.”[2] The dog appears to be an illustrative accompaniment to sketches of a swan or rabbits in the same margin, visually chasing these necessary ingredients.

Harley 1735, fol. 25r contains sketches of several cooking implements and ingredients.. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f025r. (c)British Library Board Harley MS 1735
Harley 1735, fol. 25r contains sketches of several cooking implements and ingredients. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f025r. (c)British Library Board Harley MS 1735

Perusing the cookery, one finds implements like pots, mortars and pestles, bellows, and a knife. Other less identifiable implements also reside in the margins. There are fruits and vegetables like figs, dates, plums, grapes, and even leeks! Almonds appear several times, as well as other grains, which might be wheat, sugar, salt, or possibly spices (some of the grains are particularly difficult to distinguish from one another and the recipes contain many possible suggestions). Ginger root also makes an appearance. The supply of animals is particularly healthy; fish, rabbits, chickens, quail, swan, stag, cow, and the rogue dog prowl about.[3]

A manicule on Harley 1735, fol. 21r. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f021r. (c)British Library Board Harley MS 1735
A manicule on Harley 1735, fol. 21r. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f021r. (c)British Library Board Harley MS 1735
A stag on Harley 1735, fol. 19v. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f019v. (c)British Library Board Harley MS 1735
A stag on Harley 1735, fol. 19v. http://www.bl.uk/manuscripts/Viewer.aspx?ref=harley_ms_1735_f019v. (c)British Library Board Harley MS 1735

These sketches in the margins of Harley 1735 problematize my conclusion that the cookery was primarily an aspirational text. At first glance, the number of sketches, especially manicules, might seem to indicate that the book was regularly referenced in a kitchen.[4] However, the cookery lacks the food stains and markings regularly exhibited by manuscripts used in kitchens. The artist also clearly enjoyed sketching and may have chosen to artistically render the text based on a preference for drawing certain items, rather than a correlation with preparation of foodstuffs. And perhaps most importantly, some of the recipes accompanied by sketches were almost certainly not prepared by Crophill or his household; luxury recipes like “Chaudon sauȝ of swannes” accompanied by a sketch of a swan, or “Roo in sewe” with a drawing of a stag, were simply out of reach for non-noble preparation.[5] So while this cookery is a problematic cookery, I still believe it was primarily used as an aspirational text, rather than an instructional one.

Ultimately, I am still left wondering why the illustrations were added, since it is so unusual. No contemporary cookery in England or France matches the degree of illustration. European cookbooks did not include copious illustration until the late sixteenth century with Bartolomeo Scappi’s Opera (1570) and Charles Estienne’s L’agriculture et Maison rustique (1564), and the first heavily illustrated English cookery, Robert May’s The Accomplisht Cook (1660), was not published until 1660. Perhaps the sketches in Harley 1735 were a finding aid for Crophill or another reader. Perhaps the drawings were created for a more enjoyable reading experience; modern cookbook readers are certainly familiar with this concept! Another possibility is that the sketches were created out of the sheer enjoyment of drawing and the cookery margins were an available space. Crophill’s rural surroundings in Wix, Essex, could have inspired the copious and sometimes remarkably naturalistic drawings. Or perhaps the illustrations were created as a teaching aid or storytime delight for a child in the household, with the familiar animals more akin to a Beatrix Potter tale.

In any case, these remarkable drawings deserve much more attention, and could shed light on a host of topics, from available animal breeds and vegetal varietals, household objects, or illustrative practices in late medieval manuscripts.

 

NOTES

[1] Sarah Peters Kernan, “‘For al them that delight in Cookery’: The Production and Use of Cookery Books in England, 1300–1600” (PhD diss., The Ohio State University, 2016), 64–102.

[2] fol. 18r

[3] Lois Ayoub, “John Crophill’s Books: An Edition of British Library Ms Harley 1735” (PhD diss., University of Toronto, 1994), 24–5. Ayoub catalogues the sketches in the manuscript.

[4] fols. 21r, 22r–v, 23v, 26v–27v

[5] fol. 18r and 19v

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Ancientbiotics: Medieval Medicines for Modern Infections

By Erin Connelly

In 2015, Youyou Tu jointly won the Nobel Prize in Physiology or Medicine for the development of a new therapy (Artemisinin) to treat Malaria, a disease which has been on the rise since the 1960s. Significantly, the antimalarial component was successfully extracted from the plant Artemisia annua only after consulting the instructions found in the ‘ancient literature’ of traditional herbal medicine.

As the drugs (chloroquine or quinine) used to combat the malarial parasite have experienced decreased efficacy, such is the case with a wide range of conventional antimicrobials. In fact, major pharmaceutical companies and government agencies have identified antimicrobial resistance as one of the most pressing concerns for global health. The World Health Organization (WHO) stated in September 2016 that antimicrobial resistance is ‘an increasingly serious threat to global public health that requires action across all government sectors and society.’

In response to this threat to global health, the Ancientbiotics team was formed. Originally based at the University of Nottingham, the team is an interdisciplinary group from the Arts and Sciences comprised of microbiologists, medievalists, parasitologists, wound specialists, and pharmacists, who are united by the belief that novel avenues of antibiotic discovery are crucial, along with the shared conviction that the past can inform the future. At the same time that Youyou Tu was awarded the Nobel Prize for her work with malaria, the Ancientbiotics team was investigating a tenth-century Anglo-Saxon remedy for eye infection, known as Bald’s eyesalve. The full paper is available here.

Recipe for an eyesalve from Bald’s Leechbook, England (Winchester?), mid-10th century, Royal MS 12 D XVII, f. 12v. Image and caption credit: British Library
Recipe for an eyesalve from Bald’s Leechbook, England (Winchester?), mid-10th century, Royal MS 12 D XVII, f. 12v. Image and caption credit: British Library

The 1,000-year old recipe has been shown to effectively kill a range of microbes, including, but not limited to, Methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Escherichia coli (E. coli), and leishmania. All of these species are causes of chronic, opportunistic, drug-resistant, or difficult to treat infections. While each ingredient in the eyesalve demonstrates some antimicrobial activity on its own, what is remarkable is that only in the combination of ingredients, exactly as specified by the medieval instructions, do we see the synergistic, potent antimicrobial effect in clinically realistic infection models.

An interview on Radiolab with Freya Harrison and Christina Lee is available to explain the full story of Bald’s eyesalve.

Clusters of Methicillin-resistant Staphylococcus aureus (MRSA) Image Credit: Annie Cavanagh, Wellcome Images https://creativecommons.org/licenses/by-nc-nd/4.0/
Clusters of Methicillin-resistant Staphylococcus aureus (MRSA) Image Credit: Annie Cavanagh, Wellcome Images
https://creativecommons.org/licenses/by-nc-nd/4.0/

The Ancientbiotics project also extends to medical texts of the later medieval period. The Lylye of Medicynes (Lylye) is one such text that offers a diverse range of recipes, including many promising treatments for infectious disease. The Lylye is the only extant Middle English translation of Bernard of Gordon’s Lilium medicinae; it exists in one fifteenth-century manuscript (Oxford Bodleian Library MS. Ashmole 1505). The Lylye is most notable for its pharmaceutical content. There are nearly 6000 individual ingredients in the text; 3500 of those ingredients are contained in 360 specific recipes, which represent over 110 disease states (many of which include symptoms of infection). One of the eye recipes is currently being tested at the University of Nottingham and research is ongoing to identify those ingredients which interact with the same antimicrobial synergy found in Bald’s eyesalve.

Lylye of Medicynes, Oxford Bodleian Library MS. Ashmole 1505 Image Credit: Erin Connelly
Lylye of Medicynes, Oxford Bodleian Library MS. Ashmole 1505 Image Credit: Erin Connelly

I am also working on the first published edition of the whole text of the Lylye in order to allow accessibility for increased scholarship. A forthcoming paper (2017) in the proceedings from the 8th Annual Disease, Disability, and Medicine in Medieval Europe conference (‘Treating Infected Wounds in the Middle English Translation of Bernard of Gordon’s Lilium medicinae’) conveys in greater detail the potential of this text to be mined for antimicrobial recipes.

You may read a little bit more about the Lylye of Medicynes in these short blog posts from 2014: ‘ȝif it be a pore man . . .’: Healthcare for the Rich and Poor in the Lylye of Medicynes and ‘þe best mylke is womman milke’: Does Breastmilk Heal?

As a truly interdisciplinary effort between the Arts and Sciences, the Ancientbiotics project has opened new and significant pathways to antimicrobial drug discovery, but it has also challenged the popular categorization of the medieval period as a ‘Dark Age,’ and the centuries-long pattern of dismissing medieval medical texts as ‘unenlightened’ by reason and scientific discovery. In a paradigm-shifting manner, the efficacy of medieval medicines against modern infections instead shows that medieval practitioners were operating within a lengthy tradition of observation and experimentation with recipes that may inspire present day research.