Category Archives: Ashley Buchanan

Testing Drugs and Trying Cures

By Elaine Leong and Alisha Rankin

Miniature (no. 37.181) from 15th century manuscript in Dresden: Galen, and assistant with a pestle and mortar, and a scribe in an apothecary’s shop. © Wellcome Images

As readers of this blog well know, early modern Europe was aflood with recipes and drugs. One central question has long preoccupied many of us –  just how did our historical actors assess, test and try out recipes, drugs and materia medica? A few summers ago, a group of historians of science and medicine gathered to discuss just this question. This month, we present our ideas and findings in a special issue of the Bulletin of the History of Medicine. To celebrate the launch of the special issue, several authors of the volume will share their work on The Recipes Project. Tuesday’s post revisited Ashley Buchanan and Tillmann Taape‘s report on the original 2014 conference. Over the next few weeks, we’ll learn more about the research of Erik Heinrichs, Valentina Pugliano, Alisha Rankin and Justin Rivest. Finally, Tillmann Taape, who just completed his PhD at the University Cambridge (congrats!) also adds his voice to the series by reflecting on how theme of drug testing features in his doctoral dissertation.

To get us started on our month of ‘Testing Drugs and Trying Cures’, we wanted to say a few words as the organizers and editors of the project. First, you might ask, what do we mean by ‘Testing Drugs and Trying Cures’? Over the course of the project, we found that it was useful to view ‘testing drugs’ and ‘trying cures’ as two overlapping but distinct phenomena.

As the essays in the special issue show, physicians and apothecaries developed clear rules and practices for testing drugs as materials – from sensory analysis of materia medica to chemical analysis of substances like mineral waters or alchemical medicines. This kind of ‘testing drugs’ largely focused on gaining knowledge on the substances’ medicinal properties and played a particularly significant role in the discovery and adoption of materia medica from the New World and in assessing and establishing authenticity of exotic and/or expensive medicaments.

Paolo Antonio Barbieri, The Spice Shop, 1637. Image from Wikimedia.

‘Trying cures’, on the other hand, describes the widespread practice of trying remedies and other kinds of cures on human bodies. If ‘testing drugs’ was mainly conducted by learned physicians and apothecaries, ‘trying cures’ was performed by a broad range of healers. Within the home, women and men applied and observed the effects of remedies on family and household members. Likewise, physicians and other practitioners prescribed diets, medicines and other cures to their patients, again observing and recording the effects. Ample evidence of this kind of ‘trying cures’ survive in a range historical sources from the use of ‘probatum est’ to expressions of personal experience, customisation and rejection of recipes in household recipe collections (for more on this, see posts here and here).

For us, these two categories ‘testing drugs and ‘trying cures’ serve as helpful heuristic tools to untangle the assessment practices used by early modern practitioners. We see the two categories not as separate boxes but rather as overlapping and often intertwined practices. Many healers merged testing and trying by using patient tests to determine a substance’s properties or to refine methodologies in both drug production and application. These themes of testing and trying occupied a central place in the making of medical knowledge across a vast chronological span and broad geographical regions and social contexts. The essays in the special issue examine these crucial knowledge practices in Europe c. 1300-1800 (go here for a table of contents).

Several main themes emerged from this collaborative project. First, medicine was always an experiential art and the essays in the special issue demonstrate clear continuities between the learned physicians’ uses of experience/experiment in the Middle Ages and early modern experimental interests. Learned medicine made deliberate use of experience from a very early date and pharmacy was an area where the gathering of experiential knowledge was particularly pronounced. The senses – touch, taste, smell, sight and hearing – played vital roles in determining the properties of drugs and their effects on the human body.

Concurrently, as many essays in the volume demonstrate, structured drug testing had a long history. Medieval physicians developed meticulous rules for drug testing, as Michael McVaugh’s essay shows, although they left no record of actual medical trials. This focus on establishing protocols for drug testing continues throughout the medieval and early modern period, with significant expansion in scale and scope. By the eighteenth century, the testing of mineral spa waters (in Michael Bycroft’s essay) or proprietary drugs (in Justin Rivest’s essay) became large-scale undertakings situated in learned academies and hospitals.

When taken together, the essays in the ‘Testing Drugs and Trying Cures’ special issue collectively argue that ‘experimental thinking’ played a crucial role in learned assessments of medicine and drugs throughout the Middle Ages and early modern period. From the time of Galen, drug testing was structured and evidence-based with an aim to produce transferable results. For us, this fascinating and multifaceted story of premodern drug testing enriches and extends current histories of experimentation and we hope that our explorations into topic will inspire others to join us too!

Further Reading and Acknowledgements:

This post is a very condensed version of Elaine Leong and Alisha Rankin’s ‘Testing Drugs and Trying Cures: Experiment and Medicine in Medieval and Early Modern Europe’, Bulletin of the History of Medicine, 91 (2017), 157-182. The full version of the article is available here. The entire special issue is available here.

The ‘Testing Drugs and Trying Cures’ project was funded by the Max Planck Society as part of the Minerva Research Group’s ‘Reading and Writing Nature in Early Modern Europe’.  We also extend our grateful thanks to all the participants of the 2014 workshop, the editors of the BHM and the anonymous reviewers of the articles in this special issue.

Tales from the Archives: Testing Drugs and Trying Cures Workshop Summary

In September 2016, The Recipes Project celebrated its fourth birthday. We now have over 500 posts in our archives and over 120 pages for readers to sift through. That’s a lot of material! (And thank you so much to our contributors for sharing such a wealth of knowledge on recipes.) But with so much material on the site, it’s easy for earlier pieces to be forgotten. So, the editors have decided that, every now and then, we’ll pull something out of the archives to share with our readers anew.

Over the next few weeks, The Recipes Project will feature a selection of case studies from the current issue of the Bulletin of the History of Medicine on “‘Testing Drugs and Trying Cures”. This special issue grew out of a 2014 workshop held at Max Planck Institute for the History of Science in Berlin. We were very lucky to have two then graduate students Ashley Buchanan and Tillman Taape, join us for and grateful that they took the time to pen the post below. It seems fitting to begin this month on testing drugs and trying cures with a revisit to their post. Elaine (editor).

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

By Ashley Buchanan and Tillman Taape

What did it mean to test a drug or try a cure in the early modern world? This was the central question for a group of scholars who gathered for a workshop at Max Planck Institute for the History of Science in Berlin, Germany.  Since recipes emerged as one of the key themes throughout the workshop, and because the conference’s location in Berlin made it difficult for scholars outside of Europe to attend, we thought we might share a brief summary of the “Testing Drugs and Trying Cures” papers, in the hopes that we could bring the workshop’s key ideas and discussions to a larger audience.  What emerged from an exhilarating two days of discussion and debate was the conclusion that historians of science and medicine should not privilege experiment and experimentation as fixed categories, but should understand the multiple ways in which physicians, apothecaries, artisans, institutions, and individuals in the early modern world tested, tried, investigated, experienced, modified, observed, and measured medicinal remedies and materiae medicae.

As written forms of medical and pharmaceutical knowledge and practice, recipes played an important part in the testing of drugs and cures, and our discussion raised larger questions surrounding the nature and purpose of an early modern recipe.

705px-ScuolaMedicaMiniatura
A miniature depicting the Schola Medica Salernitana from a copy of Avicenna’s Canons.  From Wikimedia Commons.

Michael McVaugh’s paper opened the discussion by exploring how medieval physicians went about testing drugs. Learned doctors in the Middle Ages might appear helplessly hidebound, and inclined to follow ancient authorities over experimentation. In contrast, McVaugh showed how a group of Montpellier physicians in the fourteenth century established something of an experimental program. Medieval physicians, however, were not testing to find a cure, but to determine the quality, strength, and effectiveness of a drug as it pertained to a particular person’s complexion. McVaugh underscored an important difference in the purpose of medieval drug testing. Physicians tested not for universal effectiveness, but to determine the quality of a drug – was it hot, cold, moist, or dry.

Duclos-title-page
Title page of the Academy’s Observations sur les eaux minérales (1675). From http://cures.hypotheses.org/the-workshop/programme-2/bycroft-michael

Although it became clear in our roundtable discussion that we should be wary of labeling such practices as obvious precursors to the experimental philosophies of the Scientific Revolution, many of the papers showed that the importance of specific tests resonated throughout the early modern period. Evan Ragland’s paper, for example, traced the use of the phrase periculum facere (‘to make a trial’) in physicians’ writings on medicine, anatomy and chemistry. Similarly, Michael Bycroft showed that French physicians and chemical experts of the Académie des Sciences became increasingly interested in the exact composition of mineral waters. Contrived tests such as color indicators or the analysis of residues after evaporation increasingly became the touchstone of proper inquiry.

McVaugh, Ragland, and Bycroft’s papers all underscored the need to understand the specific nature and purpose of testing in each historical context. Continuing to emphasize the importance of historical context, Francesco Paulo de Ceglia’s paper showed just how different the purpose of testing could be in the context of seventeenth century blood miracles in the Kingdom of Naples. Catholics tested the liquefaction of the blood of their patron saint to explore the limits of nature. By discovering nature’s limits, you could then determine what was truly miraculous. Protestants, on the other hand, tested various materials and recipes to recreate the liquefaction of blood to cast doubt on the alleged miracle.

san-gennaro
Reliquary containing a glass ampoule of San Gennaro’s blood. From La Repubblica.

In the context of testing, drugs and cures are often under scrutiny in the form of recipes detailing their production and administration. While recipes emerged from many of the papers as very important forms of knowledge, it proved virtually impossible to define exactly what a recipe was. Recipes can be very short or very detailed, ranging from a mere list of ingredients to careful step-by-step instructions. If there is one thing recipes have in common, it is the need for testing, trying, modifying and adapting to different conditions. While constructing an all-encompassing definition of a recipe proved futile, all agreed that it was fruitful to understand recipes as an important genre in early modern science and medicine.

apotheke_enhausen_l
From http://www.gn.geschichte.uni-muenchen.de/aktuelles/archiv_2011/archiv_2013/science_and_medicine/index.html

For her investigation on the testing practices of Venetian apothecaries, Valentina Pugliano emphasized the difference between experiment and experience. Venetian apothecaries were less concerned with testing drugs (in a traditional sense) than they were with the experience or truthfulness of their ingredients. Testing by inspection, smell and taste was also important in this pharmaceutical context, to ensure that the ingredients were what the merchant had promised them to be, and not a cheap substitute with inferior properties. For Pugliano’s apothecaries, the important issue that required testing was the authenticity of the ingredients rather than the efficacy of the finished product; after all, most preparations had proved their worth since antiquity. Like McVaugh, Pugliano questioned traditional “Baconian” understandings of what it meant to experiment and test and argued for more nuanced notions of testing and trying, which included observing, measuring, evaluating, and experiencing.

Image_Samir
Title page of Johannes Christophorus Homann’s Dissertatio inauguralis medica de medicinae cum geosophia nexu quam auspice deo prpitio (Hala Madgeburica, Hendelius, 1725). From http://cures.hypotheses.org/the-workshop/programme-2/boumediene-samir

With early modern Europeans’ increasing forays into the New World, however, more and more materiae medicae were found which were absent from ancient medical writings. Pliny and Dioscorides were silent on such substances as guaiacum wood, Peruvian bark or New World balsam, so their medicinal properties had to be newly investigated. Antonio Barrera-Osorio and Samir Boumediene’s papers added America, or the New World, into the discussion. Both emphasized the role of new drugs and materia medica in the rise of European experimental practices. New drugs and new medicinal recipes required new ways of testing.

Antonio Barrera-Osorio’s paper argued for an empirical culture in the Spanish empire, which was well suited to respond to these challenges. He showed how his protagonists gathered information about New World remedies from natives or travellers and experimented with ways of preparing them. Some of these drugs and recipes were deemed so important for the economy and health of the empire that the Spanish crown ordered tests in hospitals all over Castile. Samir Boumediene’s paper elaborated on the issue of making workable recipes for newly discovered drugs. Once more, taste and smell were important assays, but drugs such as guaiacum and Peruvian bark were also tested on a larger scale. Dispensing them to the poor inmates of charitable hospitals (as happened in France and Germany) helped to determine their effect, and to establish recipes, which indicated how to adjust the treatment in individual cases.

books
Andreas Cleyer, Specimen Medicinae Sinicae (Frankfurt, 1682). From http://cures.hypotheses.org/the-workshop/programme-2/hanson-marta-and-pomata-gianna

Gianna Pomata and Marta Hanson’s paper showed how recipes also functioned as vehicles of knowledge between different cultures. Recipes, as either formula or prescription, were both found in European and Chinese medical cultures. According to Pomata and Hanson, it was the familiar genre of the recipe that facilitated the transmission of Chinese pharmacology to Europe in the second half of the seventeenth century. Similarly, Carla Nappi argued that the Manchu medicinal recipes of the Qing court were spaces of encounter and medical translation in the early modern world. Pomata, Hanson, and Nappi demonstrated how the recipe served as the common ground between European and Chinese medicine and made the translation of Chinese pulse medicine and the transmission of Chinese materia medica possible in the seventeenth and eighteenth centuries.

Although recipes are difficult to characterize as a genre, it is clear that they are fascinating objects of historical study. More often than not, they are fluid rather than fixed forms of knowledge, requiring adaptation at every turn. They bring together ingredients, practices and often practitioners from all over the world, and themselves have a tendency to aggregate into larger collections. As written manifestations of gestures and processes, they play an important part in testing, assessing and modifying drugs and cures.

Dyeing to Be Cured

By Ashley Buchanan

Slipped within Anna Maria Luisa’s recipe collection is a small bound pamphlet that instructs the user how to tint or dye white marble various colors. In just sixteen pages, the unknown author details the ingredients, processes, and necessary apparatuses needed to create three different reds, two blues, three yellows, three greens, and even fake the signature black or grey veining of “pavonazzo” marble. While the secret to tinting natural looking marble was certainly valuable artisanal knowledge, it is the last three pages of the booklet that are particularly interesting. Without explanation, the pamphlet suddenly shifts topics and details “a particular secret for a styptic water that quickly stops bleeding wounds and torn guts.” The descriptive title continues by suggesting that you can “try it on a rooster by piercing its head with a sharp needle, and the rooster will heal in fifteen minutes.”

Title page of the pamphlet

The first step of the recipe instructs to dissolve a quarter of an ounce of rock alum in one ounce of “acqua rosa” (rose water), which was then added to a quart of “allume bruciato,” or calcined aluminum sulfate. This mixture was then placed in a “digestione,” which was an alchemical apparatus for distillation that dissolved a body in water or alcohol over mild heat. The recipe calls for the mixture to be heated for an hour and until clear. The second step in the recipe is to dissolve a quarter of an ounce of lead acetate in an ounce of distilled vinegar with one forth of pulverized candied sugar. For the third step, a fourth of pulverized copper sulfate from Cyprus is added to an ounce of “acqua di piantagine.” The fourth step calls for calcined red, or Roman vitriol (sulphuric acid) to be boiled with two ounces of urine from a healthy creature. The fifth and final step is to combine an ounce of strong lime into an eight of sublimated and pulverized mercury, which is “digested” to a clear heat for an hour. Once these five steps are completed, everything is to be mixed together in a flask for sublimation and to “digest” for twelve hours.

When I first came across this recipe I was unsure what to make of it, and its inclusion in a pamphlet dedicated to the act of tinting marble perplexed me. But as it turned out, this funny little pamphlet held the key to better understanding Anna Maria Luisa’s recipe collection as a whole. Recipes collected by women are traditionally viewed as domestic manuals used to safeguard the health of the home and treat commonplace illnesses. In general, and as previously discussed here on the Recipes Project, recipes were “repositories for useful knowledge” and share a desired goal to unlock nature’s secrets.[1] In the case of Anna Maria Luisa, however, useful knowledge extended beyond the preparation of simples and household medicines. Her recipe collection reveals an interest in collecting and amassing experiential alchemical knowledge. The creation of styptic water used the same ingredients, apparatuses, and alchemical processes detailed and drawn in the recipes for marble dyes that preceded it.

Detailed illustration showing how to set up the necessary alchemical apparatuses to create the marble dyes and styptic water.

In addition to highlighting one Princess’s interest in alchemy, this pamphlet also speaks to two important issues when studying early modern recipes from a modern perspective. First, science, medicine, and technology at the late Medici court existed in a world in which our modern categories of knowledge simply did not apply. In eighteenth century Florence, artisanal practices, science (or natural history), and medicine were closely connected thanks to alchemy. For the late Medici court, alchemy was not associated with the mysterious or the occult. Alchemy was an applied science that used experimental activities to investigate and transform nature. These practices produced experimental activities in metallurgy, refining salts, producing dyes and pigments, the manufacturing of man-made gemstones and stones, glass and ceramics, and the creation of chemical medicines. Each of these seemingly disparate pursuits were united by process rather than the specific product produced.

tThis early modern emphasis on process over product brings me to the second issue concerning the studying early modern recipes. While recipes are certainly important historical objects, they are often closely associated with or celebrated for the product they produce. This emphasis on product over process, however, can belie the true value of many recipes. As is in the case of the styptic water. Was Anna Maria Luisa interested in tinting marble or was she interested in better understanding complex alchemical processes that could transform nature and the human body? Thanks to this pamphlet, I now argue the latter.

 

[1] I am borrowing a working definition of early modern recipes from the Recipes Project post, “What is a Recipe?”

The Politics of Chocolate: Cosimo III’s Secret Jasmine Chocolate Recipe

By Ashley Buchanan

redi
Redi’s secret recipe, which has recently been recreated by a chocolatier in Sicily. Image Credit: http://www.italymagazine.com/featured-story/medicis-favourite-jasmine-chocolate-recreated-sicily

By 1708 the Medici grand ducal “spezieria, or pharmacy, had grown into a complex of eleven rooms located in the main ducal residence, the Palazzo Pitti. It included a medical laboratory for the production of alchemical medicines, a pharmacy for the production of herbals, syrups and powders, and a distillery for the production of medicinal waters, tinctures, and liquors. When foreign guests, dignitaries, and members of the court entered the spezieria they were greeted with stuffed exotic animals like armadillos and crocodiles. The first room of the spezieria was dedicated to one activity in particular – the consumption of chocolate. This wasn’t just any chocolate, however, it was a secret and highly coveted recipe for jasmine chocolate.

According to Francesco Redi (1626 – 1697), chocolate arrived in Florence in 1606 and was presented to Duke Ferdinando I by Francesco d’Antonio Carletti, who had just returned from a journey through the East Indies. This story is likely apocryphal, however, and it would take another five decades before drinking chocolate for its medicinal effects was popularized in Florence. Redi, who was a poet, head physician to the grand duke, scientist, and superintendent of the royal pharmacy, wrote that chocolate had become popular in noble houses and princely courts because it could fortify the stomach and improve overall health. He also explained that while the Spanish were the first to receive and manipulate chocolate, the court in Tuscany was the first to infuse chocolate with flavors such as fresh citron, limoncello, jasmine, cinnamon, vanilla, and amber.

Cosimo-III-BR
Cosimo III de’ Medici Image Credit: Wikimedia Commons

In an attempt to compete with the popularity of Spanish chocolate, Cosimo III commissioned Redi to create a proprietary chocolate recipe. Drawing on his alchemical knowledge, Redi created a complex and elaborate recipe for the grand duke. The process for creating jasmine chocolate, as it was known, took more than ten days and thousands of jasmine flowers. Not only was jasmine chocolate a testament to the duke’s wealth and the abilities of the grand ducal spezieria, it was also a symbol of Medici taste, refinement, and power. Jasmine chocolate quickly became popular at the Florentine court and a closely guarded state secret. Cosimo III forbade anyone from writing or publishing the recipe and this refined beverage could only be consumed at court or in the noblest of houses. The manipulation and production of chocolate in the grand ducal spezieria was a powerful instrument in the world of early modern statecraft. For Cosimo III chocolate was an important political statement. The acquisition of cacao from the West Indies, not New Spain, its manipulation using Medici knowledge of iatrochemistry, and ceremonial consumption at court were mechanisms of statecraft – an attempt to appear more worldly, knowledgeable, and regal than the Spanish court.

The seventeenth century was a period of intensifying centralization, rivalry, and conflict among the states of Europe. As the duke of a smaller state, Cosimo III was caught between France, England, and Spain on one side, and the Holy Roman Empire on the other. Cosimo negotiated tirelessly to appease both sides, attempting to secure important marriage alliances that would ensure the status and independence of the Grand Duchy of Tuscany. In 1689, Cosimo III was offended to learn that the Duke of Savoy had purchased the style of Royal Highness from Spain, a title Cosimo had been vying for. With the marriage of his daughter to the Elector Palatine, Cosimo was finally given royal status from the Holy Roman Emperor. Thus, from 1689 Cosimo III was recognized as His Royal Highness, The Most Serene Grand Duke of Tuscany. Cosimo III also found himself having to compete culturally and intellectually within an expanding global colonial market. Without colonies and heirs, Cosimo faced the difficult task of preserving the prestige and autonomy of Florence. In this context, the royal spezieria takes on an important significance.

Cosimo’s interest in chocolate, and pharmaceutical patronage in general, was a product of both his personal interest and political needs. At the dawn of the eighteenth century, Cosimo III still had no grandchildren. Not only did France and Spain continue to refuse to recognize Cosimo’s royal title, the new Holy Roman Emperor Joseph I also refused and attempted to extract massive feudal dues from Cosimo in 1705. Cosimo was also keenly aware that his death brought about unanswerable questions concerning Tuscan succession and independence. The grand ducal spezieria produced tangible medical therapeutics, which could prolong the health and life of the aging grand duke, so that he could protect the Medici state and manage its succession. Furthermore, therapeutics, such as secret chocolate recipes, functioned as valuable gifts that could aid in solidifying political alliances and interpersonal relationships with important elite families across Europe, relationships that could aid Cosimo as he attempted to ensure the survival of Medici prestige and autonomy of the Tuscan State.