Early Spanish settlers, administrators, and chroniclers frequently lamented how Old World diseases ravaged native communities in the New World. The famed Dominican Bartolomé de Las Casas described the ferocity of the first epidemics: “Then came a terrible plague, and almost everyone died, and very few remained.” We know much about the devastation, but less about the everyday responses of the victims of disease, especially in the Americas where death and destruction accompanied conquest and colonialism.
In colonial Mexico, native scribes and healers recorded local remedies and cures as they treated populations ravaged by endemic and epidemic sicknesses. During the eighteenth century, a series of anonymous Maya curanderos (folk healers) recorded local ideas of science and medicine in a manuscript titled Tratado de las siete planetas y otro de medicinarium (Treatise on the Seven Planets and another on Medicine). Commonly known as the Chilam Balam de Kaua, this work circulated beliefs and practices about the natural world as it passed among healers. The work synthesized European accounts of astrology with Maya understandings of the ritual calendar.
Healers recorded remedies for common afflictions and ailments that reflected the intertwined relationships of the colonizers and colonized. An early passage of the work admonished readers to hold the knowledge with respect and care. “Very good are the words of the wise. [These are] recipes in the Maya language for those Indians that want to understand this medicine. Arte, it is called for those who are sick, also for those that are strong and well. Very good are the words of the wise.” 
The healers of the Chilam Balam de Kaua recorded remedies in indigenous terms that often reflected European categories of disease. Cures addressed common illnesses, such as cough (en), cold (sis), fever (chakuil), and periodic epidemic diseases like smallpox (nohoch kak), yellow fever (vómito de sangre), or measles (sarampión). There were remedies for everyday afflictions: headache (chibal pol) and earache (chibal xicin). Others were punctuated with magical intervention, including sorcery (pulbil yaah) and evil flowers (mal floral). Treatments attempted to reduce the aches that welcomed life–childbearing (alancil) and painful swollen breast (ya umil chup)–and the pains that greeted death–bleeding (kik) and cancer (caanzeel). There were remedies to treat the difficulties of manual labor: wounds (cinpahal), swellings (chuchup), and broken bones (sayal bac). In total, the Chilam Balam de Kaua contains over three hundred and thirty remedies.
One of the numerous cures for fevers captures the interaction between Mayan and Spanish knowledge systems.
A remedy for fever (tzacal chacuil) by the ancient people, here is the consumption tree (nech bac che), its other name is fever tree. This is boiled in water to wash people who have a fever. [The affliction] is called weakness (nach bahal) in their language and this is ético in the language of the Spaniards. Then leaves of the plant should be taken with the leaves of the night herb (akab xiu), whose leaves are pleasant smelling. The same amount of leaves are mixed together and boiled until soft. They may be taken [this way]. When the water is half finished, the affirmed may be bathed with the hot water, as hot as can be allowed. Four or five times, this is done… When covered and cool, they may arise to chocolate (cacau) leaves and the night herb… The consumption tree is to be twisted with the chocolate plant.
Fevers were undoubtedly common in colonial Yucatán. As with most Yucatec remedies, the application appeared straightforward and matched symptoms with treatment. The heat of the fever was to be broken with a simmering herbal bath, followed by a concoction of herbs with chocolate.
The record keeper, however, also noted that remedy’s pre-Hispanic origins, establishing a connection to the past. In diagnosing the affliction, however, ancient Maya knowledge linked with contemporary Spanish perspectives. These fevers were called nach bahal or ético and, as such, the remedy could apply to Mayas and Spaniards alike.
The materials for the remedy were exclusively comprised of wild herbs, tying the uncontrolled disease with the unconquered frontier. While most healers may have sourced domesticated plants from herb vendors (yerbateros), this remedy required plants of the forest. The cure required knowledge of Mayan biological landscapes; to produce this remedy, the healer needed access to the untamed frontiers of the province.
This remedy, like so many of colonial Yucatán, showed that “the words of the wise” involved the convergence of distinct traditions in the everyday practices of curing. The Chilam Balam de Kaua and other medicinal manuscripts from colonial Latin America illustrate the localized processes in the production and circulation of medical knowledge in the early modern world.
 Bartolomé de Las Casas, Historia de las Indias (México: Fondo de Cultura Economica, 1951) 3: 270.
 Chilam Balam de Kaua (photostat reproductions), f. 7, Container 25,Ac. 4056, Indian Languages Collection, Library of Congress, Washington, DC.
 Chilam Balam de Kaua, f. 175.