Category Archives: Carla Nappi

Tales from the Archives: Testing Drugs and Trying Cures Workshop Summary

In September 2016, The Recipes Project celebrated its fourth birthday. We now have over 500 posts in our archives and over 120 pages for readers to sift through. That’s a lot of material! (And thank you so much to our contributors for sharing such a wealth of knowledge on recipes.) But with so much material on the site, it’s easy for earlier pieces to be forgotten. So, the editors have decided that, every now and then, we’ll pull something out of the archives to share with our readers anew.

Over the next few weeks, The Recipes Project will feature a selection of case studies from the current issue of the Bulletin of the History of Medicine on “‘Testing Drugs and Trying Cures”. This special issue grew out of a 2014 workshop held at Max Planck Institute for the History of Science in Berlin. We were very lucky to have two then graduate students Ashley Buchanan and Tillman Taape, join us for and grateful that they took the time to pen the post below. It seems fitting to begin this month on testing drugs and trying cures with a revisit to their post. Elaine (editor).

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

By Ashley Buchanan and Tillman Taape

What did it mean to test a drug or try a cure in the early modern world? This was the central question for a group of scholars who gathered for a workshop at Max Planck Institute for the History of Science in Berlin, Germany.  Since recipes emerged as one of the key themes throughout the workshop, and because the conference’s location in Berlin made it difficult for scholars outside of Europe to attend, we thought we might share a brief summary of the “Testing Drugs and Trying Cures” papers, in the hopes that we could bring the workshop’s key ideas and discussions to a larger audience.  What emerged from an exhilarating two days of discussion and debate was the conclusion that historians of science and medicine should not privilege experiment and experimentation as fixed categories, but should understand the multiple ways in which physicians, apothecaries, artisans, institutions, and individuals in the early modern world tested, tried, investigated, experienced, modified, observed, and measured medicinal remedies and materiae medicae.

As written forms of medical and pharmaceutical knowledge and practice, recipes played an important part in the testing of drugs and cures, and our discussion raised larger questions surrounding the nature and purpose of an early modern recipe.

705px-ScuolaMedicaMiniatura
A miniature depicting the Schola Medica Salernitana from a copy of Avicenna’s Canons.  From Wikimedia Commons.

Michael McVaugh’s paper opened the discussion by exploring how medieval physicians went about testing drugs. Learned doctors in the Middle Ages might appear helplessly hidebound, and inclined to follow ancient authorities over experimentation. In contrast, McVaugh showed how a group of Montpellier physicians in the fourteenth century established something of an experimental program. Medieval physicians, however, were not testing to find a cure, but to determine the quality, strength, and effectiveness of a drug as it pertained to a particular person’s complexion. McVaugh underscored an important difference in the purpose of medieval drug testing. Physicians tested not for universal effectiveness, but to determine the quality of a drug – was it hot, cold, moist, or dry.

Duclos-title-page
Title page of the Academy’s Observations sur les eaux minérales (1675). From http://cures.hypotheses.org/the-workshop/programme-2/bycroft-michael

Although it became clear in our roundtable discussion that we should be wary of labeling such practices as obvious precursors to the experimental philosophies of the Scientific Revolution, many of the papers showed that the importance of specific tests resonated throughout the early modern period. Evan Ragland’s paper, for example, traced the use of the phrase periculum facere (‘to make a trial’) in physicians’ writings on medicine, anatomy and chemistry. Similarly, Michael Bycroft showed that French physicians and chemical experts of the Académie des Sciences became increasingly interested in the exact composition of mineral waters. Contrived tests such as color indicators or the analysis of residues after evaporation increasingly became the touchstone of proper inquiry.

McVaugh, Ragland, and Bycroft’s papers all underscored the need to understand the specific nature and purpose of testing in each historical context. Continuing to emphasize the importance of historical context, Francesco Paulo de Ceglia’s paper showed just how different the purpose of testing could be in the context of seventeenth century blood miracles in the Kingdom of Naples. Catholics tested the liquefaction of the blood of their patron saint to explore the limits of nature. By discovering nature’s limits, you could then determine what was truly miraculous. Protestants, on the other hand, tested various materials and recipes to recreate the liquefaction of blood to cast doubt on the alleged miracle.

san-gennaro
Reliquary containing a glass ampoule of San Gennaro’s blood. From La Repubblica.

In the context of testing, drugs and cures are often under scrutiny in the form of recipes detailing their production and administration. While recipes emerged from many of the papers as very important forms of knowledge, it proved virtually impossible to define exactly what a recipe was. Recipes can be very short or very detailed, ranging from a mere list of ingredients to careful step-by-step instructions. If there is one thing recipes have in common, it is the need for testing, trying, modifying and adapting to different conditions. While constructing an all-encompassing definition of a recipe proved futile, all agreed that it was fruitful to understand recipes as an important genre in early modern science and medicine.

apotheke_enhausen_l
From http://www.gn.geschichte.uni-muenchen.de/aktuelles/archiv_2011/archiv_2013/science_and_medicine/index.html

For her investigation on the testing practices of Venetian apothecaries, Valentina Pugliano emphasized the difference between experiment and experience. Venetian apothecaries were less concerned with testing drugs (in a traditional sense) than they were with the experience or truthfulness of their ingredients. Testing by inspection, smell and taste was also important in this pharmaceutical context, to ensure that the ingredients were what the merchant had promised them to be, and not a cheap substitute with inferior properties. For Pugliano’s apothecaries, the important issue that required testing was the authenticity of the ingredients rather than the efficacy of the finished product; after all, most preparations had proved their worth since antiquity. Like McVaugh, Pugliano questioned traditional “Baconian” understandings of what it meant to experiment and test and argued for more nuanced notions of testing and trying, which included observing, measuring, evaluating, and experiencing.

Image_Samir
Title page of Johannes Christophorus Homann’s Dissertatio inauguralis medica de medicinae cum geosophia nexu quam auspice deo prpitio (Hala Madgeburica, Hendelius, 1725). From http://cures.hypotheses.org/the-workshop/programme-2/boumediene-samir

With early modern Europeans’ increasing forays into the New World, however, more and more materiae medicae were found which were absent from ancient medical writings. Pliny and Dioscorides were silent on such substances as guaiacum wood, Peruvian bark or New World balsam, so their medicinal properties had to be newly investigated. Antonio Barrera-Osorio and Samir Boumediene’s papers added America, or the New World, into the discussion. Both emphasized the role of new drugs and materia medica in the rise of European experimental practices. New drugs and new medicinal recipes required new ways of testing.

Antonio Barrera-Osorio’s paper argued for an empirical culture in the Spanish empire, which was well suited to respond to these challenges. He showed how his protagonists gathered information about New World remedies from natives or travellers and experimented with ways of preparing them. Some of these drugs and recipes were deemed so important for the economy and health of the empire that the Spanish crown ordered tests in hospitals all over Castile. Samir Boumediene’s paper elaborated on the issue of making workable recipes for newly discovered drugs. Once more, taste and smell were important assays, but drugs such as guaiacum and Peruvian bark were also tested on a larger scale. Dispensing them to the poor inmates of charitable hospitals (as happened in France and Germany) helped to determine their effect, and to establish recipes, which indicated how to adjust the treatment in individual cases.

books
Andreas Cleyer, Specimen Medicinae Sinicae (Frankfurt, 1682). From http://cures.hypotheses.org/the-workshop/programme-2/hanson-marta-and-pomata-gianna

Gianna Pomata and Marta Hanson’s paper showed how recipes also functioned as vehicles of knowledge between different cultures. Recipes, as either formula or prescription, were both found in European and Chinese medical cultures. According to Pomata and Hanson, it was the familiar genre of the recipe that facilitated the transmission of Chinese pharmacology to Europe in the second half of the seventeenth century. Similarly, Carla Nappi argued that the Manchu medicinal recipes of the Qing court were spaces of encounter and medical translation in the early modern world. Pomata, Hanson, and Nappi demonstrated how the recipe served as the common ground between European and Chinese medicine and made the translation of Chinese pulse medicine and the transmission of Chinese materia medica possible in the seventeenth and eighteenth centuries.

Although recipes are difficult to characterize as a genre, it is clear that they are fascinating objects of historical study. More often than not, they are fluid rather than fixed forms of knowledge, requiring adaptation at every turn. They bring together ingredients, practices and often practitioners from all over the world, and themselves have a tendency to aggregate into larger collections. As written manifestations of gestures and processes, they play an important part in testing, assessing and modifying drugs and cures.

Translating Recipes 14: Recipes in Time and Space, Part 8 – BETWEEN 3

[This is the third of a three-part posting on BETWEEN-ness in recipes and their translation. For the first two parts, see here and here.]

The following is a translation of our long-translated Manchu medical recipe in dialogue form, to explore the between-ness of the recipe through a conversation among materials: fluid, powder, and flesh. In this dialogue-shaped translation of the recipe, the major characters are the major materials interacting in the story. There are three of them – Oil, Flour, Flesh – with an early cameo by Spoon. Here, the medium of the conversation is not sound, but instead touch and movement. When speech is touch rather than sound – when voicing is touching and enabling your conversation partner to be touched, moving and enabling your partner to be moved – then the conversation works somewhat differently from what we tend to expect. Here, a single instance of touching functions as a single unit of this touch-speech. The conversation becomes a dialogue in gestures and movements over, across, with, etc. The problem that animates the dialogue is the event that stimulates and initiates movement; resolution is the circumstance in which movement eases. It is a critical issue that must be resolved: a body has been poisoned.

Between: A Dialogue in Touch

Characters:

Flour

Spoon

Flesh

Oil

 

 

Flour: (pillowed powder pile, then a smooth arc planes the surface as a small spoon cuts through to measure out a portion)

Spoon: (smoothes a concavity in the powder before cradling it away to a bowl and releasing it to its next home)

Flour: (bids farewell, dissolving into liquid and becoming something new)

Flesh: (suffering from a relationship with a substance that does not wish it well; welcomes flour in its new liquid form, into its throatspace and down and down)

Flour: (meets flesh, tries to soothe its suffering as it passes through the throat and down, roils the unkind substance poisoning the flesh and tries to bring it back up and out again)

Flesh: (pulses after ejecting the flour from itself)

Oil: (pours from container to handflesh)

Flesh: (flesh slides on flesh to warm the oil; hands slide oil over belly)

Oil: (warms and slides and soaks into belly and hands)

Flesh: (bucks and roils, breaks and bleeds, angry and unplacated)

Oil: (keeps trying; drops into meat broth – or drops into buttered milk – and mixes and swirls)

Flesh: (takes the oil back into its throatspace and down and down and retches and roils and drinks…and again…and again…)

Oil: (pours from container to handflesh)

Flesh: (still roiling; flesh slides on flesh to warm the oil; hands slide oil over belly)

Oil: (warms and slides and soaks into belly and hands…and again…and again…)

Flesh: (roiling and retching…but less…and less…and on like that more and more gently…)

Oil: (sliding and dropping…now more faintly…and gently…and more gently)

Flesh: (stillness)

Oil: (stillness)

Translating Recipes 13: Recipes in Time and Space, Part 7 – BETWEEN 2

[This is the second of a three-part posting on BETWEEN-ness in recipes and their translation. For the first part, see here.]

Happy new year, readers of the Translating Recipes series! When last we met, I was telling you about the latest exploration of “Recipes in Time and Space” with some early thoughts on between-ness in recipes and beyond. We left off by considering the characteristics of the dialogue, a storytelling genre that embodies the spirit of between. You might want to take a moment to revisit that post, which addressed the importance of some basic components of the dialogue form: character, speech, and problem. Briefly put, in translating our Manchu medicinal recipe we would expect to see characters that are involved in some sort of a relationship speaking to one another about a central problem that animates the conversation.

For your reference and reminding, here is a straightforward rendering of the Manchu recipe that has been the focus of this series of translations:

A medicinal oil eliminating (harmful) poison.

One kind [of oil] used if a person has just been poisoned.

Before eliminating the poison, after taking a flour-based drug in accordance with the 30th prescription, and after that drug causes the poison to be vomited up, spread this oil on the navel part of the stomach.

If the person has consumed so much poison that a lot of internal things are going wrong and the condition has become very serious, after taking 15 – 20 drops of the oil and combining it with either the fatty broth from boiled meat, or butter combined with milk, drink it. Having already smeared this oil on the navel part of the stomach again after 2 erin periods, the following day smear it again two times.

If this has still not eliminated the poison, after taking one or more drops of this medicinal oil again according to the prescription, if you smear it according to the prescription all will be well.

When I think of translation as rendering, my thoughts now turn to the work of STS scholar and anthropologist Natasha Myers. We recently had a chance to talk about her new book, which explores many different senses of “rendering” – separating, surrendering, modeling, deciphering, and more – in a study that emphasizes the importance of movement and kinesthetics in making knowledge. That linking of rendering, movement, and materiality has inspired how I approach translation here, and specifically how I think about translating relationships and between-ness.

With that in mind, the translation that follows – a translation of our Manchu medical recipe in a spirit that emphasizes the between-ness inherent in the text – is going to take us back to the materiality of the recipe, letting us linger over the physical matter of the story and thus helping us understand the ways that between-ness creates material experience. This is a world where speech happens not with words, but in patterns of materials. What does the voice of a powder sound like? Is sound even the right medium for understanding the voicing of a powder? Can we hear it at all, or do we instead feel this voice via touch? What does the voice of a liquid sound (or feel) like? How do these voices communicate with each other in telling a larger story?

The translation takes the form of a dialogue, and this dialogue becomes a conversation among materials: flour, oil, flesh. Each material will have its own voice. (Though we are accustomed to associating speech and voice with the sonic, here voicing is something that happens through touch, not through sound.) The conversation will allow us to explore the conversational aspects of material experience itself. Thinking about the voices of powders and liquids and flesh in this way will help us to understand materials as individuals that engage in relationships with one another, that grow and develop and change as a result of those relationships. Tune in to Thursday’s post to read the full translation!

Translating Recipes 12: Recipes in Time and Space, Part 6 – BETWEEN

By Carla Nappi

(This is part of an ongoing series of posts exploring prepositional attitudes and their translation in recipe literature. For the previous posts, check out this link.)

In the most recent posts of the “Translating Recipes” series, we have been exploring various ways that recipe literature creates relationships among bodies in space and time. (The premise undergirding this experiment is that material experience emerges from these relationships.) We have been looking specifically at the ways that prepositions and related kinds of terms function as grammatical and linguistic technologies that create proximities among bodies in time and space: with-ness, if-ness, afterness, etc. Today we’ll consider another of these tools: between-ness. Returning to the spirit from which the “Translating Recipes” project initially emerged – considering the literary form of the recipe as a vehicle for storytelling – this entry and the next will explore the way between works by looking at a storytelling genre that embodies the spirit of interaction, conversation, and between: the dialogue.

The dialogue format integrates a number of key elements. Typically, a dialogue is understood to be a conversation, an oral or written rendering of speech among characters. The dialogue might center on a problem and take the shape of an argument or debate: we can see this in some classic examples of the form that are familiar to many historians of science and medicine, including Plato’s dialogues and Galileo’s Dialogue upon the Two Main Systems of the World. This exceptionally brief description of dialogue makes reference to some important basic components of the form: character, speech, and problem. Let’s consider what these might look like in the context of a medicinal recipe.

Character. There are several ways to think about the centrality of character in the context of a recipe. We might imagine the drugs, patients, and other material actors in a recipe as they are embroiled in a drama, for example, or consider them more allegorically as characters in a fairy tale. In the context of a dialogue, the interaction of the characters is of paramount importance, and so they should explicitly be involved in some sort of a relationship. There are clear relationships in an anti-poison recipe: between poison and the drug used to treat it, poison and the patient’s body, the body and the drug. And so a translation of the recipe in this spirit would need to reflect at least one of these character relationships. (Ideally, in order to maximally explore the importance of relationships, more than one would be reflected in the translation: in that way. the relationships themselves become characters and we would be able to explore a dialogue among the relationships themselves.)

Speech. Fundamental to the nature of a written dialogue is its ability to embody and convey speech in some form: the text itself becomes a kind of vocalization, and – importantly – we as readers can imagine that the characters are not just interacting with one another, but are also performing their speech for the benefit of the audience of readers. As a result, in our translated recipe it would be important to convey this aspect of textual oratory. The form of the text would be crucial to this: each of our characters, as they explore their relationships and the problems emergent therein, would be given an opportunity to take the page and have the floor.

Problem. In many textualized dialogues, the speakers are not merely speaking, but are speaking with each other in an effort to debate or resolve something: a problem, an argument, a disagreement. There should be a sense, by the conclusion of the text, that some issue has been resolved. Our translation would need to convey this sense of dramatic conflict and ultimate resolution. In the case of the Manchu recipe that we’ve been focusing on for the “Recipes in Time and Space” series, this is a natural fit with the conditions from the which the recipe emerges: a crisis wherein a body has been poisoned and demands an immediate remedy (or as close to it as can be managed). At the successive stages of the recipe there are multiple points of possible resolution or the marked absence thereof, and these points of resolution (or not) motivate further action on the part of the readers/users of the text.

In the next post, we’ll continue these reflections and look closely at a new translation of our Manchu medical recipe that embodies a spirit of between in its form and mode of storytelling, in light of the reflections above. Tune in next time!